Journal article

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans

Jarny Choi, Tracey M Baldwin, Mae Wong, Jessica E Bolden, Kirsten A Fairfax, Erin C Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A Ramsay, Ashley P Ng, Maria Kauppi, Lynn M Corcoran, Wei Shi, Nick Wilson, Michael J Wilson, Warren S Alexander, Douglas J Hilton, Carolyn A de Graaf

NUCLEIC ACIDS RESEARCH | OXFORD UNIV PRESS | Published : 2019

Abstract

During haematopoiesis, haematopoietic stem cells differentiate into restricted potential progenitors before maturing into the many lineages required for oxygen transport, wound healing and immune response. We have updated Haemopedia, a database of gene-expression profiles from a broad spectrum of haematopoietic cells, to include RNA-seq gene-expression data from both mice and humans. The Haemopedia RNA-seq data set covers a wide range of lineages and progenitors, with 57 mouse blood cell types (flow sorted populations from healthy mice) and 12 human blood cell types. This data set has been made accessible for exploration and analysis, to researchers and clinicians with limited bioinformatics..

View full abstract

Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

National Health and Medical Research Council [Independent Research Institutes Infrastructure Support Scheme, 1113577 to W.S.A., D.J.H, 1058344 to W.S.A., 1048087 to D.J.H., C.M., GNT0637403 to J.E.B., GNT1035229 to C.d.G.]; Australian Cancer Research Foundation; Victorian State Government Operational Infrastructure Support and CSL Limited. Funding for open access charge: The Walter and Eliza Hall Institute.