Journal article
Regulatory T Cells Suppress Effector T Cell Proliferation by Limiting Division Destiny
MR Dowling, A Kan, S Heinzel, JM Marchingo, PD Hodgkin, ED Hawkins
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2018
Abstract
Understanding how the strength of an effector T cell response is regulated is a fundamental problem in immunology with implications for immunity to pathogens, autoimmunity, and immunotherapy. The initial magnitude of the T cell response is determined by the sum of independent signals from antigen, co-stimulation and cytokines. By applying quantitative methods, the contribution of each signal to the number of divisions T cells undergo (division destiny) can be measured, and the resultant exponential increase in response magnitude accurately calculated. CD4+CD25+Foxp3+ regulatory T cells suppress self-reactive T cell responses and limit pathogen-directed immune responses before bystander damag..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
MD, PH and EH were supported by National Health and Medical Research Council of Australia (NHMRC) Fellowships. JM was the recipient of an Australian Postgraduate Award, an Edith Moffat Scholarship from The Walter and Eliza Hall Institute and Sydney Parker Smith Postdoctoral Research Fellowship from the Cancer Council of Victoria. This work was supported by the Australian Health and Medical Research Council (program grant 1054925, project grant 105783), Victorian State Government operational infrastructure support and Australian Government NHMRC IRIIS.