Journal article
First genome-wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes
DL Cousminer, E Ahlqvist, R Mishra, MK Andersen, A Chesi, MI Hawa, A Davis, KM Hodge, JP Bradfield, K Zhou, VC Guy, M Akerlund, M Wod, LG Fritsche, H Vestergaard, J Snyder, K Højlund, A Linneberg, A Käräjämäki, I Brandslund Show all
Diabetes Care | AMER DIABETES ASSOC | Published : 2018
DOI: 10.2337/dc18-1032
Abstract
OBJECTIVE Latent autoimmune diabetes in adults (LADA) shares clinical features with both type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise definition of LADA. Understanding its genetic basis is one potential strategy to gain insight into appropriate classification of this diabetes subtype. RESEARCH DESIGN AND METHODS We performed the first genome-wide association study of LADA in case subjects of European ancestry versus population control subjects (n = 2,634 vs. 5,947) and compared against both case subjects with type 1 diabetes (n = 2,454 vs. 968) and type 2 diabetes (n = 2,779 vs. 10,396). RESULTS The leading genetic signals were principally shared with ty..
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Awarded by Instituto de Salud Carlos III
Funding Acknowledgements
D.L.C. is supported by American Diabetes Association grant 1-17-PDF-077. D.M. is supported by CIBERDEM, Instituto de Salud Carlos III (Spain). B.O.B. is supported by the German Research Council (SFB 518, A1), the state of Baden-Wuerttemberg, and a Ministry of Education, Singapore startup grant. S.F.A.G. is supported by the National Institutes of Health (R01-DK-085212) and the Children's Hospital of Philadelphia Daniel B. Burke Endowed Chair for Diabetes Research.