A Randomized Controlled Trial of Adherence to a 24-Month Home-Based Physical Activity Program and the Health Benefits for Older Adults at Risk of Alzheimer's Disease: The AIBL Active-Study

Kay L Cox; Elizabeth Cyarto; Kathryn A Ellis; David Ames; Patricia Desmond; Pramit Phal; Matthew J Sharman; Cassandra Szoeke; Christopher C Rowe; Colin L Masters; Emily You; Sally Burrows; Michelle MY Lai; Nicola T Lautenschlager

Journal article

A Randomized Controlled Trial of Adherence to a 24-Month Home-Based Physical Activity Program and the Health Benefits for Older Adults at Risk of Alzheimer's Disease: The AIBL Active-Study

Kay L Cox, Elizabeth Cyarto, Kathryn A Ellis, David Ames, Patricia Desmond, Pramit Phal, Matthew J Sharman, Cassandra Szoeke, Christopher C Rowe, Colin L Masters, Emily You, Sally Burrows, Michelle MY Lai, Nicola T Lautenschlager

JOURNAL OF ALZHEIMERS DISEASE | IOS PRESS | Published : 2019

DOI: 10.3233/JAD-180521

Download PDF

Abstract

BACKGROUND: Previous studies have demonstrated that physical activity (PA) interventions can improve physical and cognitive outcomes in older adults, but most have been relatively short in duration (<1 year) with a few having specifically targeting individuals at risk of developing Alzheimer's disease. OBJECTIVE: To examine adherence and physical health outcomes in a 24-month home-based PA intervention in older adults at risk of Alzheimer's disease. METHODS: Participants 60 years and older with mild cognitive impairment (MCI) or subjective memory complaints (SMC) with at least 1 cerebrovascular risk factor recruited from The Australian Imaging Biomarkers and Lifestyle Flagship Study of Aging..

View full abstract

University of Melbourne Researchers

Kathryn Ellis Author Psychiatry

Colin Masters Author Florey Department of Neuroscience and Mental Health

Cassandra Szoeke Author Medicine - Royal Melbourne Hospital

Christopher Rowe Author Florey Department of Neuroscience and Mental Health

Patricia Desmond Author Radiology

Related Projects (4)

WOMEN'S HEALTHY AGEING COGNITIVE PROJECT

The changes of Alzheimer’s disease occur a decade prior to symptoms. Therefore we need longitudinal prospective data over 20 years to determ..

THE ASSOCIATIONS BETWEEN COGNITIVE DECLINE AND GENETIC POLYMORPHISMS, HORMONES AND CARDIOVQSCULAR RISK FACTORS IN WOMEN

Dementia, a major cause of morbidity and mortality in ageing women, has been linked to hormonal changes and genes. If factors associated wit..

MODIFIABLE RISK FACTORS FOR COGNITIVE IMPAIRMENT IN AGEING

This study focuses on age-related decline in cognitive function in midlife.Early detection of people at risk will allow the introduction of ..

A RANDOMISED CLINICAL TRIAL OF PHYSICAL ACTIVITY TO DELAY THE PROGRESSION OF CEREBROVASCULAR PATHOLOGY

The aim of this randomised clinical trial is to establish whether a 24 months physical activity (PA) program for older adults with memory pr..

Grants

Awarded by Australian National Health and Medical Research Council

Awarded by Centre of Research Excellence in Cognitive Health from the Australian National Health and Medical Research Council

Awarded by NHMRC

Funding Acknowledgements

This paper was supported by a project grant (1005942) and the Centre of Research Excellence in Cognitive Health (1100579) from the Australian National Health and Medical Research Council.Funding for the AIBL study is provided by the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund (SIEF) in partnership with Edith Cowan University (ECU), Mental Health Research institute (MHRI), Alzheimer's Australia (AA), National Ageing Research Institute (NARI), Austin Health, CogState Ltd., Hollywood Private Hospital, Sir Charles Gardner Hospital. The study also receives funding from the National Health and Medical Research Council, the Dementia Collaborative Research Centers program (DCRC2) and The McCusker Alzheimer's Research Foundation and Operational Infrastructure Support from the Government of Victoria. The Australian Postgraduate Award supported the stipend for ML to be involved in this project.CS is supported by the NHMRC (grant numbers: 547600, 1032350, and 1062133).