Journal article
Effect of Fluid Bolus Therapy on Extravascular Lung Water Measured by Lung Ultrasound in Children With a Presumptive Clinical Diagnosis of Sepsis
E Long, A O'Brien, T Duke, E Oakley, FE Babl
Journal of Ultrasound in Medicine | WILEY | Published : 2019
DOI: 10.1002/jum.14842
Abstract
Objectives: Fluid bolus therapy for the treatment of sepsis may lead to the accumulation of extravascular lung water (EVLW) and result in respiratory dysfunction. We aimed to assess changes in EVLW using lung ultrasound (US) in children with a presumptive clinical diagnosis of sepsis after fluid bolus therapy and correlate these changes with respiratory signs. Methods: This work was a prospective observational study set in the emergency department of the Royal Children's Hospital. Children meeting international consensus criteria for sepsis receiving fluid bolus therapy were included. Respiratory signs were recorded, and lung US examinations were performed immediately before, 5 minutes after..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank the resuscitation staff in the Emergency Department of the Royal Children's Hospital for their enthusiasm and help with recruiting patients for this study. We also thank the families of the enrolled children for allowing study procedures to be performed during a stressful time of their hospitalization. Last, we thank the children who acted as study participants for their involvement; improving their care was the primary motivator for this study. This study was supported in part by a Windermere Foundation Doctoral Scholarship in Health, a National Health and Medical Research Council Centre of Research Excellence (Canberra, Australian Capital Territory, Australia) grant for pediatric emergency medicine (GNT1058560), the Victorian Government's Infrastructure Support Program (Melbourne, Victoria, Australia), a Shields Research Entry Scholarship provided by the Royal Australasian College of Physicians (Sydney, New South Wales, Australia), a clinical sciences theme grant provided by the Royal Children's Hospital Foundation (Melbourne, Victoria, Australia). Dr Babl was supported by a Melbourne Children's clinician scientist fellowship (Melbourne, Victoria, Australia) and a National Health and Medical Research Council practitioner fellowship.