Journal article

Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention

Chongshan Dai, Xilong Xiao, Jichang Li, Giuseppe D Ciccotosto, Roberto Cappai, Shusheng Tang, Elena K Schneider-Futschik, Daniel Hoyer, Tony Velkov, Jianzhong Shen

ACS CHEMICAL NEUROSCIENCE | AMER CHEMICAL SOC | Published : 2019

Abstract

Neurotoxicity is one major unwanted side-effects associated with polymyxin (i.e., colistin and polymyxin B) therapy. Clinically, colistin neurotoxicity is characterized by neurological symptoms including dizziness, visual disturbances, vertigo, confusion, hallucinations, seizures, ataxia, and facial and peripheral paresthesias. Pathologically, colistin-induced neurotoxicity is characterized by cell injury and death in neuronal cell. This Review covers our current understanding of polymyxin-induced neurotoxicity, its underlying mechanisms, and the discovery of novel neuroprotective agents to limit this neurotoxicity. In recent years, an increasing body of literature supports the notion that p..

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Grants

Awarded by Key Projects in Chinese National Science and Technology Pillar Program during the 12th Five-year Plan Period


Funding Acknowledgements

This study was supported by Key Projects in Chinese National Science and Technology Pillar Program during the 12th Five-year Plan Period (2015BAD11B03, to CD., S.T.). T.V. and E.K.S.-F. are supported by the Australian National Health and Medical Research Council (NHMRC).