Journal article

The Diverse Family of MR1-Restricted T Cells

Nicholas A Gherardin, James McCluskey, Jamie Rossjohn, Dale I Godfrey

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2018

Abstract

Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR α- and TCR β-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Program


Awarded by Australian Research Council (ARC) Centre of Excellence Grant


Funding Acknowledgements

This work was supported by National Health and Medical Research Council (NHMRC) Program Grant 1113293 and Australian Research Council (ARC) Centre of Excellence Grant CE140100011. D.I.G. is supported by an NHMRC Senior Principal Research Fellowship. J.R. is supported by an ARC Laureate Fellowship.