Effects of androgen and oestrogen on IGF pathways controlling phallus growth
Yu Chen, Hongshi Yu, Andrew Pask, Asao Fujiyama, Yutaka Suzuki, Sumio Sugano, Geoff Shaw, Marilyn B Renfree
REPRODUCTION | BIOSCIENTIFICA LTD | Published : 2019
The development of the mammalian phallus involves hormone-dependent mesenchymal-epithelial signalling mechanisms that contribute to urethral closure and regulation of phallus elongation and growth. In marsupials, most differentiation and growth of the phallus occurs post-natally, making them amenable to direct hormone treatment. Expression of IGFs, FGFs, EFNB2, MAFB, DLX5 and AP-1 mRNAs in the phallus at day 50 post-partum (pp) were altered after treatment of tammar wallaby young from day 20 to 40 pp with androgen, oestrogen or after castration at day 25 pp. However, the most interesting changes occurred in the IGF pathway genes. Androgen treatment upregulated IGF1 in female phalluses and oe..View full abstract
This study was supported by a grant from the National Health and Medical Research Council of Australia to M B R, A J P, G S, H Y and J D W.