Bond Graph Representation of Chemical Reaction Networks
Peter Gawthrop, Edmund J Crampin
IEEE TRANSACTIONS ON NANOBIOSCIENCE | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | Published : 2018
The Bond Graph approach and the Chemical Reaction Network approach for modeling the biomolecular systems were developed independently. This paper brings together the two approaches by providing a bond graph interpretation of the chemical reaction network concept of complexes. Both closed and open systems are discussed. The method is illustrated using a simple enzyme-catalyzed reaction and a trans-membrane transporter.
Peter Gawthrop would like to thank the Melbourne School of Engineering for its support via a Professorial Fellowship. The authors would like to thank Ivo Siekmann for alerting them to - and the anonymous reviewers for helpful comments on the manuscript.