Touchscreen testing reveals clinically relevant cognitive abnormalities in a mouse model of schizophrenia lacking metabotropic glutamate receptor 5
Ariel M Zeleznikow-Johnston, Thibault Renoir, Leonid Churilov, Shanshan Li, Emma L Burrows, Anthony J Hannan
SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2018
Metabotropic glutamate receptor 5 (mGlu5) has been implicated in certain forms of synaptic plasticity and cognitive function. mGlu5 knockout (KO) mice and mGlu5 antagonists have been previously used to study the pathophysiology of schizophrenia as they have been shown respectively to display or induce endophenotypes relevant to schizophrenia. While schizophrenia presents with generalized cognitive impairments, the cognitive phenotype of mice lacking mGlu5 has so far only been explored using largely hippocampal-dependent spatial and contextual memory tasks. To address this, we used a touchscreen system to assess mGlu5 KO mice for pairwise visual discrimination, reversal learning, and extincti..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by ARC FT3 Future Fellowship
Awarded by NHMRC
We would like to thank past and present laboratory members for useful discussions and technical assistance. We thank Daniel Drieberg and Brett Purcell for their technical assistance. We thank Andrew Lawrence for donating the MTEP used in this study. This work was supported by a National Health and Medical Research Council (NHMRC) Project Grant (GNT1126885) to A.J.H., T.R. and E.L.B. E.L.B. is supported by a NHMRC Australian Research Council (ARC) Dementia Research Development Fellowship. A.J.H. is an NHMRC Principal Research Fellow (GNT1117148) and has been supported by an ARC FT3 Future Fellowship (FT100100835). T.R. is an NHMRC Research Fellow and has been supported by an ARC Discovery Early Career Researcher Award. A.M.Z.J. is supported by the Australian Government Research Training Program Scholarship. We would also like to acknowledge the operational infrastructure support from the State Government of Victoria.