Journal article

PD-1 Expression in HIV-Specific CD8( ) T cells Before Antiretroviral Therapy Is Associated With HIV Persistence

Yanina Ghiglione, Cesar Trifone, Jimena Salido, Ajantha Rhodes, Maria Julia Ruiz, Maria Laura Polo, Horacio Salomon, Natalia Laufer, Omar Sued, Sharon R Lewin, Gabriela Turk

JAIDS Journal of Acquired Immune Deficiency Syndromes | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

BACKGROUND: The persistence of latently infected T cells remains the principal barrier to HIV cure. Understanding how the early immune responses shape persistence of HIV on antiretroviral therapy (ART) will be fundamental for potential eradication. Here, we aimed to determine the relationship between CD8 T-cell function and phenotype before therapy and HIV persistence on ART. METHODS: Blood samples from 29 individuals enrolled during primary HIV infection (at baseline and every 3 months up to 2 years post-ART initiation) were obtained. HIV-specific T-cell function and expression of the activation markers were evaluated before ART by flow cytometry. Cell-associated HIV DNA and unspliced (US)-..

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University of Melbourne Researchers

Grants

Awarded by Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT; PICT2015)


Awarded by ANPCyT/GlaxoSmithKline (PICTO-GSK)


Awarded by Universidad de Buenos Aires (UBACyT)


Awarded by National Institutes of Health


Funding Acknowledgements

Supported by grants from the Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT; PICT2015, Grant # 1004) and the HIV Research Trust (2015) to Y.G.; from ANPCyT/GlaxoSmithKline (PICTO-GSK, Grant # 2013/0006) and from Universidad de Buenos Aires (UBACyT 2013-2016, Grant #20020120200263BA and UBACyT 2017, Grant #20020160100008BA) to G.T. S.R.L. is supported by the National Institutes of Health (Grant numbers U19 AI096109 and UM1AI126611) and the National Health and Medical Research Council of Australia. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.