Orthostatic hypotension and physical functioning in older adults: A systematic review and meta-analysis

A Mol; EM Reijnierse; PTS Bui Hoang; RJA van Wezel; CGM Meskers; AB Maier

Journal article

Orthostatic hypotension and physical functioning in older adults: A systematic review and meta-analysis

A Mol, EM Reijnierse, PTS Bui Hoang, RJA van Wezel, CGM Meskers, AB Maier

Ageing Research Reviews | ELSEVIER IRELAND LTD | Published : 2018

DOI: 10.1016/j.arr.2018.10.007

Abstract

Background: Orthostatic hypotension (OH) may negatively affect physical functioning and aggravate morbidities, but existing evidence is contradictory. Methods: MEDLINE (from 1946), PubMed (from 1966) and EMBASE databases (from 1947) were systematically searched for studies on the association of OH and physical functioning in older adults, categorized as: balance, gait characteristics, walking speed, Timed Up and Go time, handgrip strength (HGS), physical frailty, exercise tolerance, physical activity, activities of daily living (ADL), and performance on the Hoehn and Yahr scale (HY) and Unified Parkinson's Disease Rating Scale (UPDRS). Study quality was assessed using the Newcastle Ottawa Sc..

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University of Melbourne Researchers

Esmee Reijnierse Author

Andrea Maier Author

Grants

Awarded by Horizon 2020 Framework Programme

Funding Acknowledgements

This work was supported by the Dutch Technology Foundation TTW [NeuroCIMT perspective grant 2015]; and the European Union's Horizon 2020 research and innovation program [No 689238, 2015; No 675003, 2015]. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.