Journal article

Investigation of group A Streptococcus immune responses in an endemic setting, with a particular focus on J8

Patricia Therese Campbell, Hannah Frost, Pierre R Smeesters, Joseph Kado, Michael F Good, Michael Batzloff, Nicholas Geard, Jodie McVernon, Andrew Steer

VACCINE | ELSEVIER SCI LTD | Published : 2018

Abstract

Sustained control of group A Streptococcus (GAS) infections in settings of poverty has proven to be challenging, and an effective vaccine may be the most practical long-term strategy to reduce GAS-related disease burden. Candidate GAS vaccines based on the J8 peptide have demonstrated promising immunogenicity in mice, however, less is known about the role of J8 antibodies in the human immune response to GAS infection. We analysed the stimulation of J8 antibodies in response to infection, and the role of existing J8 antibodies in protection against subsequent infection, using data collected in the Fijian population: (1) cross sectional population serosurvey; (2) paired serum collection for as..

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Grants

Awarded by National Institute of Allergy and Infectious Diseases


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Centre of Research Excellence PRISM2


Awarded by NHMRC Principal Research Fellowship


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This study was funded by the National Institute of Allergy and Infectious Diseases (grant U01AI60579); National Health and Medical Research Council (NHMRC) project grant (GNT1051297); NHMRC Centre of Research Excellence PRISM<SUP>2</SUP> (GNT1058804); and the Murdoch Children's Research Institute of Melbourne, Australia. JM is supported by an NHMRC Principal Research Fellowship (GNT 1117140).