Domain-specific physical activity and the risk of colorectal cancer: results from the Melbourne Collaborative Cohort Study
Shahid Mahmood, Dallas R English, Robert J MacInnis, Amalia Karahalios, Neville Owen, Roger L Milne, Graham G Giles, Brigid M Lynch
BMC CANCER | BMC | Published : 2018
BACKGROUND: Physical activity reduces the risk of colorectal cancer (CRC), but the relevant evidence derives primarily from self-reported recreational and occupational activity. Less is known about the contribution of other domains of physical activity, such as transport and household. We examined associations between domain-specific physical activities and CRC risk within the Melbourne Collaborative Cohort Study. METHODS: Analyses included 23,586 participants who were free from invasive colorectal cancer and had completed the International Physical Activity Questionnaire-Long Form at follow-up 2 (2003-2007). Cox regression, with age as the time metric, was used to estimate hazard ratios (HR..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by National Breast Cancer Foundation
The MCCS cohort was supported by Australian National Health and Medical Research Council (NHMRC) grants 209057 and 396414 for study design and by Cancer Council Victoria for data collection. Recruitment was funded by VicHealth and Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry (VCR) and the Australian Institute of Health and Welfare (AIHW), including the National Death Index and the Australian Cancer Database. SM is a recipient of a Melbourne International Fee Remission Scholarship (MIFRS) and a Melbourne International Research Scholarship (MIRS) for his doctorate studies. Lynch is supported by a fellowship from the National Breast Cancer Foundation (ECF-15-012).