Journal article
Multiplicity of infection is a poor predictor of village-level plasmodium vivax and P. falciparum population prevalence in the Southwest Pacific
C Koepfli, A Waltmann, M Ome-Kaius, LJ Robinson, I Mueller
Open Forum Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2018
DOI: 10.1093/ofid/ofy240
Abstract
Across 8101 individuals in 46 villages, the proportion of Plasmodium spp. multiple clone infections (0%-53.8%) did not reflect prevalence by quantitative polymerase chain reaction (qPCR; 1.9%-38.4%), except for P. vivax in Solomon Islands (P < .001). Thus this parameter was not informative to identify transmission foci. In contrast, prevalence by microscopy and qPCR correlated well.
Grants
Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
This work was supported by the NIH International Centers of Excellence in Malaria Research (19 AI089686), the TransEpi consortium funded by the Bill & Melinda Gates Foundation, and National Health and Medical Research Council (NHMRC) Project Grant funding (1021544). This work was made possible through Victorian State Government Operational Infrastructure Support and the Australian Government NHMRC Independent Research Institute Infrastructure Support Scheme (IRIISS). C.K. was supported by a fellowship from the Swiss National Science Foundation (P2BSP3_ 151880). L.J.R. was supported by an National Health and Medical Research Council Early Career Fellowship (1016443). I.M. is supported by an NHMRC Senior Research Fellowship.