Outcome of Acetaminophen-Induced Acute Liver Failure Managed Without Intracranial Pressure Monitoring or Transplantation
Jennifer Porteous, Luca Cioccari, Paolo Ancona, Eduardo Osawa, Kelly Jones, Paul Gow, Peter Angus, Stephen Warrillow, Rinaldo Bellomo
LIVER TRANSPLANTATION | WILEY | Published : 2019
Acetaminophen-induced acute liver failure (ALF) may require emergency liver transplantation (LT) in the presence of specific criteria, and its management may also include intracranial pressure (ICP) monitoring in selected patients at high risk of cerebral edema. We aimed to test the hypothesis that management of such patients without ICP monitoring or LT would yield outcomes similar to those reported with conventional management. We interrogated a database of all patients treated in an intensive care unit for acetaminophen-induced ALF between November 2010 and October 2016 and obtained relevant information from electronic medical records. We studied 64 patients (58 females) with a median age..View full abstract
This study was supported by grants from the Austin Hospital Intensive Care Trust Fund.