Antibody Targets on the Surface of Plasmodium falciparum-Infected Erythrocytes That Are Associated With Immunity to Severe Malaria in Young Children
Jo-Anne Chan, Michelle J Boyle, Kerryn A Moore, Linda Reiling, Zaw Lin, Wina Hasang, Marion Avril, Laurens Manning, Ivo Mueller, Moses Laman, Timothy Davis, Joseph D Smith, Stephen J Rogerson, Julie A Simpson, Freya JI Fowkes, James G Beeson
Journal of Infectious Diseases | Oxford University Press | Published : 2019
BACKGROUND: Sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the microvasculature contributes to pathogenesis of severe malaria in children. This mechanism is mediated by antigens expressed on the IE surface. However, knowledge of specific targets and functions of antibodies to IE surface antigens that protect against severe malaria is limited. METHODS: Antibodies to IE surface antigens were examined in a case-control study of young children in Papua New Guinea presenting with severe or uncomplicated malaria (n = 448), using isolates with a virulent phenotype associated with severe malaria, and functional opsonic phagocytosis assays. We used genetically modified isolate..View full abstract
Awarded by National Institute of Allergy and Infectious Diseases, National Institutes of Health
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Funding was provided by the National Health and Medical Research Council of Australia (program grant and senior research fellowship to J. G. Beeson; senior research fellowship to J. A. S.; Early Career Fellowship and Career Development award to M. J. B.) and the National Institute of Allergy and Infectious Diseases, National Institutes of Health (grant number 5R01AI114766-04 to J. D. S.). J. G. B., F. J. F., I. M., S. J. R., and J. A. S. were supported in part by the Australian Centre for Research Excellence in Malaria Elimination funded by the National Health and Medical Research Council (NHMRC). The authors gratefully acknowledge support for the Burnet Institute from the Victorian Operational Infrastructure Support Program and the NHMRC Independent Research Institutes Infrastructure Scheme.