CPP-ACP Promotes SnF2 Efficacy in a Polymicrobial Caries Model
SG Dashper, P Shen, CPC Sim, SW Liu, CA Butler, HL Mitchell, T D'Cruze, Y Yuan, B Hoffmann, GD Walker, DV Catmull, C Reynolds, EC Reynolds
JOURNAL OF DENTAL RESEARCH | SAGE PUBLICATIONS INC | Published : 2019
Dental caries is associated with plaque dysbiosis, leading to an increase in the proportions of acidogenic and aciduric bacteria at the expense of alkali-generating commensal species. Stannous fluoride (SnF2) slows the progression of caries by remineralization of early lesions but has also been suggested to inhibit glycolysis of aciduric bacteria. Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) promotes fluoride remineralization by acting as a salivary biomimetic that releases bioavailable calcium and phosphate ions, and the peptide complex has also been suggested to modify plaque composition. We developed a polymicrobial biofilm model of caries using 6 bacterial species represen..View full abstract
This study was supported by the Australian Government, Department of Industry, Innovation and Science. C.P.C. Sim is supported by a Singaporean National Medical Research Council Research Training Fellowship. The late Nathan Cochrane is thanked for his invaluable input into this study. The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.