Journal article
Altered Populations of Unconventional T Cell Lineages in Patients with Langerhans Cell Histiocytosis
J Mitchell, E Kvedaraite, T von Bahr Greenwood, JI Henter, DG Pellicci, SP Berzins, G Kannourakis
Scientific Reports | NATURE PORTFOLIO | Published : 2018
Abstract
Langerhans cell histiocytosis (LCH) lesions are defined by the presence of CD1a+/CD207+ myeloid cells, but many other immune cells are present including unconventional T cells, which have powerful immunoregulatory functions. Unconventional T cell lineages include mucosal-associated invariant T (MAIT) cells, type I natural killer T (NKT) cells and gamma-delta (γδ) T cells, which are associated with many inflammatory conditions, although their importance has not been studied in LCH. We characterized their phenotype and function in blood and lesions from patients with LCH, and identified a deficiency in MAIT cell frequency and abnormalities in the subset distributions of γδ T cells and NKT cell..
View full abstractGrants
Awarded by Histiocytosis Association
Funding Acknowledgements
We are thankful for the participation of patients and healthy donors in this study. This work was supported by a grant funded by the Histiocytosis Association and by grants from the Swedish Research Council and the Swedish Children's Cancer Foundation. J.M. is supported by an Australian Government Research Training Program (RTP) Stipend and RTP Fee-Offset Scholarship through Federation University Australia. DGP is supported by an NHMRC Career Development Fellowship APP1144308. We are grateful for the generous gift of CD1d and MR1 and monomers from the Godfrey and McCluskey laboratories, respectively (Dept. Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Parkville, Australia). We also thank all board members, staff and students at the Fiona Elsey Cancer Research Institute for their support.