Structural Variants and Selective Sweep Foci Contribute to Insecticide Resistance in the Drosophila Genetic Reference Panel
Paul Battlay, Pontus B Leblanc, Llewellyn Green, Nandita R Garud, Joshua M Schmidt, Alexandre Fournier-Level, Charles Robin
G3-GENES GENOMES GENETICS | OXFORD UNIV PRESS INC | Published : 2018
Patterns of nucleotide polymorphism within populations of Drosophila melanogaster suggest that insecticides have been the selective agents driving the strongest recent bouts of positive selection. However, there is a need to explicitly link selective sweeps to the particular insecticide phenotypes that could plausibly account for the drastic selective responses that are observed in these non-target insects. Here, we screen the Drosophila Genetic Reference Panel with two common insecticides; malathion (an organophosphate) and permethrin (a pyrethroid). Genome-wide association studies map survival on malathion to two of the largest sweeps in the D. melanogaster genome; Ace and Cyp6g1 Malathion..View full abstract
Josefa Gonzalez, Phil Batterham/Batterham lab (stocks), Trudy Mackay, NECTAR computational services. We also thank Owain Edwards for discussion and the CSIRO for scholarship support of PB.