Journal article
Modulation of NKG2D, NKp46, and Ly49C/I facilitates natural killer cell-mediated control of lung cancer
L Shi, K Li, Y Guo, A Banerjee, Q Wang, UM Lorenz, M Parlak, LC Sullivan, OO Onyema, S Arefanian, EB Stelow, DL Brautigan, TNJ Bullock, MG Brown, AS Krupnick
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2018
Abstract
Natural killer (NK) cells play a critical role in controlling malignancies. Susceptibility or resistance to lung cancer, for example, specifically depends on NK cell function. Nevertheless, intrinsic factors that control NK cell-mediated clearance of lung cancer are unknown. Here we report that NK cells exposed to exogenous major histocompatibility class I (MHCI) provide a significant immunologic barrier to the growth and progression of malignancy. Clearance of lung cancer is facilitated by up-regulation of NKG2D, NKp46, and other activating receptors upon exposure to environmental MHCI. Surface expression of the inhibitory receptor Ly49C/I, on the other hand, is down-regulated upon exposure..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
A.S.K. was supported by Grants PO1AI116501 (Washington University in St. Louis), 1I01BX002299 (Salem VA Medical Center), and R41CA224520 (University of Virginia), and work in the manuscript was partially supported by the University of Virginia (UVA) Cancer Center National Cancer Institute Grant P30-CA044579-23 and UVA Cancer Center Bioinformatics Core via Grant P30CA044579.