Pathophysiological Interactions between Chronic Kidney Disease and Cardiac Remodelling

Abstract

Purpose In the setting of chronic kidney disease, cardiovascular disease is the most common cause of death. However, the underlying pathophysiological interactions between two organs are not fully understood. Therefore, we investigated the pathophysiological changes that occur when myocardial infarction (MI) follows a kidney injury (5/6 nephrectomy ‐ STNx). Methods STNx or Sham surgery was induced in male Sprague Dawley rats initially with each group randomised to receive MI or Sham surgery (left anterior descending coronary artery ligation) 4 weeks later. Animals were followed for a further 8 w..