Role of Nox2 in diabetic kidney disease
Young-Hyun You, Shinichi Okada, San Ly, Karin Jandeleit-Dahm, David Barit, Tamehachi Namikoshi, Kumar Sharma
American Journal of Physiology. Renal physiology | AMER PHYSIOLOGICAL SOC | Published : 2013
NADPH oxidase (Nox) isoforms have been implicated in contributing to diabetic microvascular complications, but the functional role of individual isoforms in diabetic kidney are unclear. Nox2, in particular, is highly expressed in phagocytes and may play a key inflammatory role in diabetic kidney disease. To determine the role of Nox2, we evaluated kidney function and pathology in wild-type (WT; C57BL/6) and Nox2 knockout (KO) mice with type 1 diabetes. Diabetes was induced in male Nox2 KO and WT mice with a multiple low-dose streptozotocin protocol. Groups were studied for kidney disease after 8 and 20 wk of diabetes. Hyperglycemia and body weights were similar in WT and Nox2 KO diabetic mic..View full abstract
Awarded by National Institutes of Health
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Awarded by Grants-in-Aid for Scientific Research
This study was supported by grants from the National Institutes of Health (R01 DK-053867, 1DP3DK-094352-01 and U01 DK-060995), a VA Merit Award, and the Juvenile Diabetes Research Foundation to K. Sharma.