Journal article
Moraxella catarrhalis Restriction–Modification Systems Are Associated with Phylogenetic Lineage and Disease
LV Blakeway, A Tan, R Lappan, A Ariff, JL Pickering, CS Peacock, CC Blyth, CM Kahler, BJ Chang, D Lehmann, LAS Kirkham, TF Murphy, MP Jennings, LO Bakaletz, JM Atack, IR Peak, KL Seib
Genome Biology and Evolution | OXFORD UNIV PRESS | Published : 2018
DOI: 10.1093/gbe/evy226
Open access
Abstract
Moraxella catarrhalis is a human-adapted pathogen, and a major cause of otitis media (OM) and exacerbations of chronic obstructive pulmonary disease. The species is comprised of two main phylogenetic lineages, RB1 and RB2/3. Restriction–modification (R-M) systems are among the few lineage-associated genes identified in other bacterial genera and have multiple functions including defense against foreign invading DNA, maintenance of speciation, and epigenetic regulation of gene expression. Here, we define the repertoire of R-M systems in 51 publicly available M. catarrhalis genomes and report their distribution among M. catarrhalis phylogenetic lineages. An association with phylogenetic lineag..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (NHMRC) (Career Development Fellowship and Project Grant 1021631 to K.L.S.; Project Grant 1099279 to K.L.S., J.M.A., and L.O.B.; Career Development Fellowship to LSK; Program Grant 1071659 and Principal Research Fellowship 1138466 to M.P.J.; Program Grant 353514 to D.L.), the Australian Research Council (Discovery Grant 170104691 to M.P.J.), the Garnett Passe and Rodney Williams Memorial Foundation (Fellowship to A.T. and Grant in Aid Supplementation to K.L.S. and J.M.A.), National Institutes of Health grant R01 DC012200 to T.F.M., an Australian Government Research Training Program (RTP) Scholarship to L.V.B. and R.L., Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, The University of Western Australia top-up Scholarship to R.L. Collection of BRPRU strains was funded by National Institute of Allergy and Infectious Diseases #N01 AI30040 (L.O.B. subcontract PI). Collection of Kalgoorlie study strains was funded through NHMRC Project Grant 212044 and two Healthway grants (6028 and 10564).Funding for open access charge: Australian NHMRC National Health and Medical Research Council (NHMRC).