Journal article

Convergence of virulence and multidrug resistance in a single plasmid vector in multidrug-resistant Klebsiella pneumoniae ST15

Margaret Lam, Kelly Wyres, Ryan Wick, Louise Judd, Aasmund Fostervold, Kathryn Holt, Iren Høyland Löhr

Published : 2018

Abstract

SYNOPSIS Background Multidrug resistance (MDR) and hypervirulence (hv) are typically observed in separate Klebsiella pneumoniae populations. However, convergent strains with both properties have been documented and potentially pose a high risk to public health in the form of invasive infections with limited treatment options. Objectives To characterize the genetic determinants of virulence and antimicrobial resistance (AMR) in two ESBL-producing K. pneumoniae isolates belonging to the international MDR clone ST15. Methods The complete genome sequences of both isolates, including their plasmids, were resolved using Illumina and Oxford Nanopore sequencing. Results Both isolates carried large m..

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University of Melbourne Researchers

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