Journal article

Yersiniabactin, Colibactin and Wider Resistome Contribute to Enhanced Virulence and Persistence of KPC-2-Producing Klebsiella pneumoniae CG258 in South America

Louise Cerdeira, Fernanda Esposito, Margaret Lam, Kelly Wyres, Ryan Wick, Louise Judd, Marcos Cunha, Terezinha Knöbl, Bruna Araújo, Rosineide Ribas, Sebastian Cifuentes, Jesus Tamariz, Maria Bueno, Gabriela Francisco, Doroti Garcia, Gerardo Gonzalez-Rocha, Gabriel Gutkind, Kathryn Holt, Nilton Lincopan

Published : 2018

Abstract

The emergence and dissemination of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) is a worrisome public health issue compromising the treatment and outcome of infections caused by this pathogen. We performed a detailed virulome and resistome analysis of representative KPC- and/or CTX-M-producing K. pneumoniae belonging to clonal group (CG) 258 (sequence types ST11, ST258, ST340, ST437), circulating in Argentina, Brazil, Chile, Colombia and Peru; with further evaluation of the virulence behavior using the Galleria mellonella infection model. Genomic analysis of K. pneumoniae strains recovered from the human-animal-environment interface revealed a wide resistome characteriz..

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