Conference Proceedings
Functional neuroplasticity in response to cerebello-thalamic injury underpins the clinical presentation of tremor in multiple sclerosis
FMC Boonstra, G Noffs, T Perera, VG Jokubaitis, AP Vogel, BA Moffat, H Butzkueven, A Evans, A van der Walt, SC Kolbe
Multiple Sclerosis Journal | SAGE PUBLICATIONS LTD | Published : 2020
Abstract
Background: Tremor is present in almost half of multiple sclerosis (MS) patients. The lack of understanding of its pathophysiology is hampering progress in development of treatments. Objectives: To clarify the structural and functional brain changes associated with the clinical phenotype of upper limb tremor in people with MS. Methods: Fifteen healthy controls (46.1 ± 15.4 years), 27 MS participants without tremor (46.7 ± 11.6 years) and 42 with tremor (46.6 ± 11.5 years) were included. Tremor was quantified using the Bain score (0–10) for overall severity, handwriting and Archimedes spiral drawing. Functional magnetic resonance imaging activations were compared between participants groups d..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
[ "V. Jokubaitis: received travel support from Biogen, Merck, and Sanofi, and received speaker's honoraria from Biogen. She receives fellowship funding from Multiple Sclerosis Research Australia.", "A Vogel: consults to Takeda and Pfizer. He is Chief Science Officer of Redenlab. He receives grant and fellowship funding from the National Health and Medical Research Council of Australia.", "H Butzkueven: served on scientific advisory boards for Biogen, Roche, Merck, Novartis, Teva and Sanofi and has received conference travel support from Novartis, Biogen and Merck. He serves on steering committees for trials conducted by Merck, Biogen and Novartis, and has received research support from Novartis, Biogen, NHMRC Australia, MS Research Australia and the UKMS Trust." ]