Journal article
Aspirin in coronary artery surgery: 1-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery trial
PS Myles, JA Smith, J Kasza, B Silbert, M Jayarajah, T Painter, DJ Cooper, S Marasco, J McNeil, JS Bussières, S McGuinness, MTV Chan, S Wallace, A Forbes
Journal of Thoracic and Cardiovascular Surgery | MOSBY-ELSEVIER | Published : 2019
Abstract
Background: Aspirin may reduce the risk of vascular graft thrombosis after cardiovascular surgery. We previously reported the 30-day results of a trial evaluating aspirin use before coronary artery surgery. Here we report the 1-year outcomes evaluating late thrombotic events and disability-free survival. Methods: Using a factorial design, we randomly assigned patients undergoing coronary artery surgery to receive aspirin or placebo and tranexamic acid or placebo. The results of the aspirin comparison are reported here. The primary 1-year outcome was death or severe disability, the latter defined as living with a modified Katz activities of daily living score .10). Conclusions: In patients un..
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Awarded by National Institute for Health Research
Funding Acknowledgements
The study sponsor was the Alfred Hospital, Melbourne, Australia. The study was supported by grants from the Australian National Health and Medical Research Council (NHMRC, ID 334015 and 1009203), the Australian and New Zealand College of Anaesthetists, and the UK National Institute for Health Research. Paul Myles is supported by an Australian NHMRC Practitioner Fellowship.