Conference Proceedings

Lipid-related genetic polymorphisms significantly modulate the association between lipids and disability progression in multiple sclerosis

Yan Zhang, Yuan Zhou, Ingrid AF van der Mei, Steve Simpson, Anne-Louise Ponsonby, Robyn M Lucas, Prudence Tettey, Jac Charlesworth, Karam Kostner, Bruce V Taylor, Keith Dear, Terry Dwyer, Leigh Blizzard, Simon Broadley, Trevor Kilpatrick, David Williamsand Jeanette Lechner-Scott, Cameron Shawand Caron Chapman, Alan Coulthard, Michael P Pender, Patricia Valery

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | BMJ PUBLISHING GROUP | Published : 2019

Abstract

OBJECTIVE: To investigate whether lipid-related or body mass index (BMI)-related common genetic polymorphisms modulate the associations between serum lipid levels, BMI and disability progression in multiple sclerosis (MS). METHODS: The association between disability progression (annualised Expanded Disability Status Scale (EDSS) change over 5 years, ΔEDSS) and lipid-related or BMI-related genetic polymorphisms was evaluated in a longitudinal cohort (n=184), diagnosed with MS. We constructed a cumulative genetic risk score (CGRS) of associated polymorphisms (p<0.05) and examined the interactions between the CGRS and lipid levels (measured at baseline) in predicting ΔEDSS. All analyses were co..

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