Lipid-related genetic polymorphisms significantly modulate the association between lipids and disability progression in multiple sclerosis
Yan Zhang, Yuan Zhou, Ingrid AF van der Mei, Steve Simpson, Anne-Louise Ponsonby, Robyn M Lucas, Prudence Tettey, Jac Charlesworth, Karam Kostner, Bruce V Taylor, Keith Dear, Terry Dwyer, Leigh Blizzard, Simon Broadley, Trevor Kilpatrick, David Williamsand Jeanette Lechner-Scott, Cameron Shawand Caron Chapman, Alan Coulthard, Michael P Pender, Patricia Valery
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | BMJ PUBLISHING GROUP | Published : 2019
OBJECTIVE: To investigate whether lipid-related or body mass index (BMI)-related common genetic polymorphisms modulate the associations between serum lipid levels, BMI and disability progression in multiple sclerosis (MS). METHODS: The association between disability progression (annualised Expanded Disability Status Scale (EDSS) change over 5 years, ΔEDSS) and lipid-related or BMI-related genetic polymorphisms was evaluated in a longitudinal cohort (n=184), diagnosed with MS. We constructed a cumulative genetic risk score (CGRS) of associated polymorphisms (p<0.05) and examined the interactions between the CGRS and lipid levels (measured at baseline) in predicting ΔEDSS. All analyses were co..View full abstract
Awarded by Australian National Health and Medical Research Council
The AusLong Study was funded by the Australian National Health and Medical Research Council (NHMRC APP544922).