Journal article
Patterns of Cortical Structures and Cognition in Antipsychotic-Naïve Patients With First-Episode Schizophrenia: A Partial Least Squares Correlation Analysis
K Jessen, RCW Mandl, B Fagerlund, KB Bojesen, JM Raghava, HG Obaid, MB Jensen, LB Johansen, M Nielsen, C Pantelis, E Rostrup, BY Glenthøj, BH Ebdrup
Biological Psychiatry Cognitive Neuroscience and Neuroimaging | ELSEVIER | Published : 2019
Abstract
Background: Schizophrenia is associated with alterations in cortical structures and cognitive impairments, but antipsychotic medication may affect these measures. We investigated patterns of relationships between cortical structures and cognitive domains in antipsychotic-naïve patients with first-episode schizophrenia. Methods: T1-weighted 3T magnetic resonance imaging was performed in 105 patients and 136 healthy control subjects. Using FreeSurfer, we obtained measurements of cortical thickness, surface area, and mean curvature. Using an extensive neurocognitive battery including the Danish Adult Reading Test and subtests from the Cambridge Neuropsychological Test Automated Battery, we obta..
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Awarded by Eli Lilly and Company
Funding Acknowledgements
[ "BYG is the leader of a Lundbeck Foundation Centre of Excellence for Clinical Intervention and Neuropsychiatric Schizophrenia Research, which is partially financed by an independent grants from the Lundbeck Foundation (Grant Nos. R13-A1349, R25-A2701, and R155-2013-16337) based on international review and partially financed by the Mental Health Services in the Capital Region of Denmark, the University of Copenhagen, Danish Agency for Science and Technology and Innovation (Grant No. 271-08-0690), and other foundations. The Danish Medical Research Council also supported the study (Grant No. 271-06-0410). The Marie and August Krogh Foundation and the Gerhard Lind Fund also supported the study. In addition, KJ and KBB received Ph.D. grants from the Research Foundation of the Mental Health Services, the Capital Region of Denmark. All grants are the property of the Mental Health Services in the Capital Region of Denmark and administrated by them. This work was also supported by a grant from the Lundbeck Foundation (Grant No. R246-2016-3237) and by a Senior Principal Research Fellowship (Grant No. 1105825) from the Australian National Health and Medical Research Council [to CP]).", "BYG has received a research grant from Lundbeck A/S for another independent investigator-initiated study. BHE has been part of the Advisory Board of Eli Lilly Danmark A/S, Janssen-Cilag, and Takeda Pharmaceutical Company Ltd. and has received lecture fees from Bristol-Myers Squibb, Otsuka Pharma Scandinavia AB, and Eli Lilly and Company. CP has participated on Advisory Boards for Janssen-Cilag, AstraZeneca, Lundbeck, and Servier and has received honoraria for talks presented at educational meetings organized by AstraZeneca, Janssen-Cilag, Eli Lilly and Company, Pfizer, Lundbeck, and Shire. The other authors report no biomedical financial interests or potential conflicts of interest." ]