Journal article

Alternate Subthalamic Nucleus Deep Brain Stimulation Parameters to Manage Motor Symptoms of Parkinson's Disease: Systematic Review and Meta-analysis

Zachary J Conway, Peter A Silburn, Wesley Thevathasan, Karen O' Maley, Geraldine A Naughton, Michael H Cole

MOVEMENT DISORDERS CLINICAL PRACTICE | WILEY | Published : 2019

Abstract

Background: The use of alternate frequencies, amplitudes, and pulse widths to manage motor symptoms in Parkinson's disease (PD) patients with subthalamic nucleus deep brain stimulation (STN-DBS) is of clinical interest, but currently lacks systematic evidence. Objective/Hypothesis: Systematically review whether alternate STN-DBS settings influence the therapy's efficacy for managing PD motor symptoms. Methods: Systematic searches identified studies that; involved bilateral STN-DBS PD patients; manipulated ≥ 1 STN-DBS parameter (e.g., amplitude); assessed ≥ 1 motor symptom (e.g., tremor); and contrasted the experimental and chronic stimulation settings. A Mantel-Haenszel random-effects meta-a..

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Grants

Funding Acknowledgements

The lead author (ZC) was supported by an Australian Government Research Training Program Scholarship. The funding body did not contribute to data collection or data analysis and played no part in the decision to prepare and publish this manuscript.