Journal article

Treatment choice for early-stage hepatocellular carcinoma in real-world practice: impact of treatment stage migration to transarterial chemoembolization and treatment response on survival

Stuart K Roberts, Alessia Gazzola, John Lubel, Paul Gow, Sally Bell, Amanda Nicoll, Anouk Dev, Michael A Fink, Siddharth Sood, Virginia Knight, Hong Thai, Eldho Paul, Gauri Mishra, Ammar Majeed, William Kemp

Scandinavian Journal of Gastroenterology | TAYLOR & FRANCIS LTD | Published : 2018

Abstract

OBJECTIVE: The objectives of our study were firstly to characterize the treatment stage migration phenomenon in early (Barcelona Clinic Liver Cancer [BCLC]-0/A) stage hepatocellular carcinoma (HCC) by comparing the efficacy of curative therapies with trans-arterial chemoembolization [TACE] and secondly, determining baseline and on-treatment predictors of survival. METHODS: All patients within BCLC-0/A stage from six tertiary hospitals who received curative therapy with either resection, transplantation, or ablation or TACE as first-line treatment were included in the analyses. The primary endpoint was overall survival; secondary end-points were transplant-free survival and recurrence-free su..

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