Journal article

Stress-driven discovery in the natural products: A gateway towards new drugs

Syed Shams ul Hassan, Hui-zi Jin, Tareq Abu-Izneid, Abdur Rauf, Muhammad Ishaq, Hafiz Ansar Rasul Suleria

BIOMEDICINE & PHARMACOTHERAPY | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | Published : 2019

Abstract

Elicitation by chemical means including heavy metals is one of a novel technique for drug discoveries. In this review, the effect of heavy metals on animal, plants and microorganisms for the production of novel compounds with the unique structures has been discussed. The number of parameters such as metal concentration, type, dose, treatment schedule, duration of metal exposure, and nutrient composition are significant factors altering the secondary metabolites production. The detailed illustrated diagram representing the mode of action of metal stress has also been discussed. This is the first article reporting all the novel compounds produced from plants and microorganisms in response to m..

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University of Melbourne Researchers

Grants

Awarded by NSFC


Awarded by Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products


Awarded by Scientific Foundation of Shanghai China


Awarded by National Key Research and Development Program of China


Funding Acknowledgements

The work was supported by Professor of Chang Jiang Scholars Program, NSFCs (81520108030, 21472238), Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (16DZ2280200), the Scientific Foundation of Shanghai China (13401900103, 13401900101), the National Key Research and Development Program of China (2017YFC1700200).