Regulating gene expression in animals through RNA endonucleolytic cleavage
Karen Gu, Lawrence Mok, Mark MW Chong
Heliyon | ELSEVIER SCI LTD | Published : 2018
The expression of any gene must be precisely controlled for appropriate function. This expression can be controlled at various levels. This includes epigenetic regulation through DNA methylation or histone modifications. At the posttranscriptional level, regulation can be via alternative splicing or controlling messenger RNA (mRNA) stability. RNA cleavage is one way to control mRNA stability. For example, microRNA (miRNA)-induced mRNA cleavage has long been recognised in plants. RNA cleavage also appears to be widespread in other kingdoms of life, and it is now clear that mRNA cleavage plays critical functions in animals. Although miRNA-induced mRNA cleavage can occur in animals, it is not a..View full abstract
Awarded by National Health and Medical Research Council of Australia
The Chong laboratory was supported by grants from the National Health and Medical Research Council of Australia (#1122395 and #1122384). MMWC is also a recipient of a National Health and Medical Research Council Senior Research Fellowship.