A ryanodine receptor agonist promotes the consolidation of long-term memory in young chicks
Kathryn D Baker, Thomas M Edwards, Nikki S Rickard
BEHAVIOURAL BRAIN RESEARCH | ELSEVIER SCIENCE BV | Published : 2010
Young chicks were trained on a weakly reinforced variant of a single-trial discrimination avoidance task which typically fails to consolidate the long-term memory stage. The ryanodine receptor (RyR) agonist 4-chloro-m-cresol (500 microM, i.c.) persistently promoted high retention until at least 24 h post-training when administered between the time of training and 20 min post-training. The consolidation of the long-term memory stage by RyR activation implicates intracellular calcium release in triggering long-term memory.