Rationale for Intervention and Dose Is Lacking in Stroke Recovery Trials: A Systematic Review
Karen Borschmann, Kathryn S Hayward, Audrey Raffelt, Leonid Churilov, Sharon Kramer, Julie Bernhardt
STROKE RESEARCH AND TREATMENT | HINDAWI LTD | Published : 2018
Background: The ineffectiveness of most complex stroke recovery trials may be explained by inadequate intervention design. The primary aim of this review was to explore the rationales given for interventions and dose in stroke rehabilitation randomised controlled trials (RCTs). Methods: We searched the Cochrane Stroke Group library for RCTs that met the following criteria: (1) training based intervention; (2) >50% participants who were stroke survivors; (3) full peer-reviewed text; (4) English language. We extracted data on 16 quality items covering intervention dose (n= 3), trial design (n= 10), and risk of bias (n= 3) and 18 items related to trial method. Logistic regression analyses were ..View full abstract
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Awarded by National Health and Medical Research Council NHMRC Fellowship
The authors thank Professor Tammy Hoffmann (Centre for Research in Evidence-Based Practice, Bond University) for provision of the initial Cochrane review search. Julie Bernhardt was supported by National Health and Medical Research Council NHMRC Fellowship (1058635). The Florey Institute of Neuroscience and Mental Health acknowledges support from the Victorian Government, in particular funding from the Operational Infrastructure Support Grant.