Fetal membrane architecture, aging and inflammation in pregnancy and parturition

R Menon; LS Richardson; M Lappas

Journal article

Fetal membrane architecture, aging and inflammation in pregnancy and parturition

R Menon, LS Richardson, M Lappas

Placenta | W B SAUNDERS CO LTD | Published : 2019

DOI: 10.1016/j.placenta.2018.11.003

Abstract

Preterm birth is the single major cause of infant mortality. Short and long term outcomes for infants are often worse in cases of preterm premature rupture of the fetal membranes (pPROM). Thus, increased knowledge of the structure characteristics of fetal membranes as well as the mechanisms of membrane rupture are essential if we are to develop effective treatment strategies to prevent pPROM. In this review, we focus on the role of inflammation and senescence in fetal membrane biology.

University of Melbourne Researchers

Martha Lappas Author

Related Projects (3)

R. DOUGLAS WRIGHT BIOMEDICAL CAREER DEVELOPMENT AWARD - (UNDERSTANDING THE MECHANISMS THAT REGULATE THE ONSET OF HUMAN LABOUR AND DELIVERY)

UNDERSTANDING THE MECHANISMS THAT REGULATE INFECTION-INDUCED PRETERM BIRTH

Being born too early is the major cause of perinatal morbidity and mortality and accounts for the majority of neonatal deaths. The aim of th..

UNDERSTANDING WHAT TRIGGERS BIRTH

Being born too early is the major cause of perinatal morbidity and mortality and accounts for the majority of neonatal deaths. The aim of th..

Grants

Awarded by National Institute of Child Health and Human Development

Funding Acknowledgements

M. Lappas's has been supported by fellowships from National Health and Medical Research Council (NHMRC) (grant numbers 454777 and 1047025) and the University of Melbourne. The work from M. Lappas's laboratory was funded by project grants from NHMRC (grant numbers. 367615 and 1058786), Melbourne Research Grant Scheme (MRGS), ANZ Charitable Trust (Medical Research and Technology Grant), Norman Beischer Medical Research Foundation and the Mercy Research Foundation.