Journal article

Enrichment of Cytomegalovirus-induced NKG2C( ) Natural Killer Cells in the Lung Allograft

Christopher M Harpur, Sanda Stankovic, Abbie Kanagarajah, Jacqueline ML Widjaja, Bronwyn J Levvey, Yvonne Cristiano, Greg I Snell, Andrew G Brooks, Glen P Westall, Lucy C Sullivan

Transplantation | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

BACKGROUND: In lung transplant recipients, immunosuppressive medications result in impaired antiviral immunity and a propensity for cytomegalovirus (CMV) reactivation within the lung allograft. Natural killer (NK) cells play a key role in immunity to CMV, with an increase in the proportion of NK cells expressing activating CD94-NKG2C receptors in the blood being a strong correlate of CMV infection. Whether a similar increase in NKG2C NK cells occurs in lung transplant recipients following CMV reactivation in the allograft and if such cells contribute to viral control remains unclear. METHODS: In this pilot study, we longitudinally assessed the frequency and phenotype of NKG2C NK cells in the..

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Grants

Funding Acknowledgements

A.G.W. was supported by National Health and Medical Research Council (NHMRC) Program Grant and L.C.S. and G.P.W. were supported by NHMRC Project Grant.