STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury
Amar Abdullah, Moses Zhang, Tony Frugier, Sammy Bedoui, Juliet M Taylor, Peter J Crack
JOURNAL OF NEUROINFLAMMATION | BMC | Published : 2018
BACKGROUND: Traumatic brain injury (TBI) represents a major cause of disability and death worldwide with sustained neuroinflammation and autophagy dysfunction contributing to the cellular damage. Stimulator of interferon genes (STING)-induced type-I interferon (IFN) signalling is known to be essential in mounting the innate immune response against infections and cell injury in the periphery, but its role in the CNS remains unclear. We previously identified the type-I IFN pathway as a key mediator of neuroinflammation and neuronal cell death in TBI. However, the modulation of the type-I IFN and neuroinflammatory responses by STING and its contribution to autophagy and neuronal cell death afte..View full abstract
This study was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia to PJC and JMT.