Journal article

Latent Iron Deficiency as a Marker of Negative Symptoms in Patients with First-Episode Schizophrenia Spectrum Disorder

Sung-Wan Kim, Robert Stewart, Woo-Young Park, Min Jhon, Ju-Yeon Lee, Seon-Young Kim, Jae-Min Kim, Paul Amminger, Young-Chul Chung, Jin-Sang Yoon

NUTRIENTS | MDPI | Published : 2018

Abstract

Iron deficiency may alter dopaminergic transmission in the brain. This study investigated whether iron metabolism is associated with negative symptoms in patients with first-episode psychosis. The study enrolled 121 patients with first-episode schizophrenia spectrum disorder, whose duration of treatment was 2 months or less. Negative symptoms were measured using the Positive and Negative Syndrome Scale (PANSS) and Clinician-Rated Dimensions of Psychosis Symptom Severity (Dimensional) scale of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Prominent negative symptoms were defined as moderate or severe negative symptoms on the Dimensional scale of the DSM-5. ..

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Grants

Awarded by Korean Mental Health Technology R&D Project, Ministry of Health Welfare


Awarded by National Research Foundation of Korea


Funding Acknowledgements

This study was supported by a grant from the Korean Mental Health Technology R&D Project, Ministry of Health & Welfare (HM15C1140) and a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF-2017R1A2B4010830).