A collaborative analysis of individual participant data from 19 prospective studies assesses circulating Vitamin D and prostate cancer risk

RC Travis; A Perez-Cornago; PN Appleby; D Albanes; CE Joshu; PL Lutsey; AM Mondul; EA Platz; SJ Weinstein; TM Layne; KJ Helzlsouer; K Visvanathan; D Palli; PH Peeters; B Bueno-de-Mesquita; A Trichopoulou; MJ Gunter; KK Tsilidis; MJ Sanchez; A Olsen; H Brenner; B Schottker; L Perna; B Holleczek; P Knekt; H Rissanen; BB Yeap; L Flicker; OP Almeida; YYE Wong; JM Chan; EL Giovannucci; MJ Stampfer; G Ursin; RE Gislefoss; T Bjørge; HE Meyer; R Blomhoff; S Tsugane; N Sawada; DR English; DW Eyles; AK Heath; EJ Williamson; J Manjer; J Malm; M Almquist; L Le Marchand; CA Haiman; LR Wilkens; JM Schenk; CM Tangen; A Black; MB Cook; WY Huang; RG Ziegler; RM Martin; FC Hamdy; JL Donovan; DE Neal; M Touvier; S Hercberg; P Galan; M Deschasaux; TJ Key; NE Allen

Journal article

A collaborative analysis of individual participant data from 19 prospective studies assesses circulating Vitamin D and prostate cancer risk

RC Travis, A Perez-Cornago, PN Appleby, D Albanes, CE Joshu, PL Lutsey, AM Mondul, EA Platz, SJ Weinstein, TM Layne, KJ Helzlsouer, K Visvanathan, D Palli, PH Peeters, B Bueno-de-Mesquita, A Trichopoulou, MJ Gunter, KK Tsilidis, MJ Sanchez, A Olsen Show all

Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2019

DOI: 10.1158/0008-5472.CAN-18-2318

Abstract

Previous prospective studies assessing the relationship between circulating concentrations of vitamin D and prostate cancer risk have shown inconclusive results, particularly for risk of aggressive disease. In this study, we examine the association between prediagnostic concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and the risk of prostate cancer overall and by tumor characteristics. Principal investigators of 19 prospective studies provided individual participant data on circulating 25(OH)D and 1,25(OH)2D for up to 13,462 men with incident prostate cancer and 20,261 control participants. ORs for prostate cancer by study-specific fifths of season-st..

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University of Melbourne Researchers

Dallas English Author

Grants

Awarded by National Cancer Institute

Funding Acknowledgements

This work was supported by Cancer Research UK grant C8221/A19170 and involved centralized pooling, checking, and data analysis. Details of funding for the original studies are in the relevant publications (and see Supplementary Materials).