The Role of BACH2 in T Cells in Experimental Malaria Caused by Plasmodium chabaudi chabaudi AS
Chelsea L Edwards, Marcela Montes de Oca, Fabian de Labastida Rivera, Rajiv Kumar, Susanna S Ng, Yulin Wang, Fiona H Amante, Kohei Kometani, Tomohiro Kurosaki, Tom Sidwell, Axel Kallies, Christian R Engwerda
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2018
BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) is a transcription factor best known for its role in B cell development. More recently, it has been associated with T cell functions in inflammatory diseases, and has been proposed as a master transcriptional regulator within the T cell compartment. In this study, we employed T cell-specific Bach2-deficient (B6.Bach2 ΔT ) mice to examine the role of this transcription factor in CD4+ T cell functions in vitro and in mice infected with Plasmodium chabaudi AS. We found that under CD4+ T cell polarizing conditions in vitro, Th2, and Th17 helper cell subsets were more active in the absence of Bach2 expression. In mice inf..View full abstract
This work was made possible through Queensland State Government funding. The research was supported by grants and fellowships from the National Health and Medical Research Council of Australia, as well as an Australian Post-graduate Awards through the University of Queensland, School of Medicine and Griffith University, a Sylvia and Charles Viertel Fellowship to AK and an INSPIRE Fellowship to RK provided by the Indian government Department of Science and Technology (DST).