Journal article

Mapping the EORTC-QLQ-C30 to the EQ-5D-3L: An Assessment of Existing and Newly Developed Algorithms

Fionn Woodcock, Brett Doble

Med Decis Making | SAGE PUBLICATIONS INC | Published : 2018


OBJECTIVES: To assess the external validity of mapping algorithms for predicting EQ-5D-3L utility values from EORTC QLQ-C30 responses not previously validated and to assess whether statistical models not previously applied are better suited for mapping the EORTC QLQ-C30 to the EQ-5D-3L. METHODS: In total, 3866 observations for 1719 patients from a longitudinal study (Cancer 2015) were used to validate existing algorithms. Predictive accuracy was compared to previously validated algorithms using root mean squared error, mean absolute error across the EQ-5D-3L range, and for 10 tumor-type specific samples as well as using differences between estimated quality-adjusted life years. Thirteen new ..

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Funding Acknowledgements

Cancer 2015 is funded by the Victorian Cancer Agency Translational Research Program. We thank all the cancer patients who agreed to participate in the cohort. We acknowledge the contributions of the following staff and collaborators of this multisite cohort: John P. Parisot, Kristy Barnes-Cullen, Kate Crough, Jessica McDonald, Emma Galligan, Ann Officer, Anne Fennessy, and Sonia Mailer from the Peter MacCallum Cancer Centre; Kate Richards, Laura Zamurs, Kate Hurford, Rachel Osborne, and Jennifer MacIndoe from Cabrini Health; Carolyn Wielens, Lea-Anne Harrison, Judi Broad, Robert Swiger, Tina Smith, and Anne Woollett from The Andrew Love Cancer Centre, Barwon Health; Sandra Robinson, Marcelle Hennig, and Ashlin Keane from Oncology Trials Department, South West Healthcare; Monica Merceica, Stefanie Hartley, Pat Bugeja, Lidia Veca, Christopher Bates, and Nicole Ng from The Royal Melbourne Hospital, Melbourne Health.