Journal article
Electrical Field Shaping Techniques in a Feline Model of Retinal Degeneration
TC Spencer, JB Fallon, CJ Abbott, PJ Allen, A Brandli, CD Luu, SB Epp, MN Shivdasani
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS | IEEE | Published : 2018
Abstract
The majority of preclinical studies investigating multi-electrode field shaping stimulation strategies for retinal prostheses, have been conducted in normally-sighted animals. This study aimed to reassess the effectiveness of two electrical field shaping techniques that have been shown to work in healthy retinae, in a more clinically relevant animal model of photoreceptor degeneration. Four cats were unilaterally blinded via intravitreal injections of adenosine triphosphate. Cortical responses to traditional monopolar (MP) stimulation, focused multipolar (FMP) stimulation and two-dimensional current steering were recorded. Contrary to our previous work, we found no significant difference bet..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors wish to thank Ceara McGowan, Ali Almasi, Felix Aplin, Kerry Halupka, Faith Lamont, Rodney Millard, Alison Neil, Alexia Saunders, Evgeni Sergeev, Dimitra Stathopoulos, and Patrick Thien for technical assistance. Funding was provided by the National Health and Medical Research Council (NHMRC) Project Grant #1063093. The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program.