Electrical Field Shaping Techniques in a Feline Model of Retinal Degeneration.
Thomas C Spencer, James B Fallon, Carla J Abbott, Penny J Allen, Alice Brandli, Chi D Luu, Stephanie B Epp, Mohit N Shivdasani
Annu Int Conf IEEE Eng Med Biol Soc | Published : 2018
The majority of preclinical studies investigating multi-electrode field shaping stimulation strategies for retinal prostheses, have been conducted in normally-sighted animals. This study aimed to reassess the effectiveness of two electrical field shaping techniques that have been shown to work in healthy retinae, in a more clinically relevant animal model of photoreceptor degeneration. Four cats were unilaterally blinded via intravitreal injections of adenosine triphosphate. Cortical responses to traditional monopolar (MP) stimulation, focused multipolar (FMP) stimulation and two-dimensional current steering were recorded. Contrary to our previous work, we found no significant difference bet..View full abstract