Journal article
Modelling heterogeneity in host susceptibility to tuberculosis and its effect on public health interventions
IM Wangari, J Trauer, L Stone
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2018
Abstract
A tuberculosis (TB) model that accounts for heterogeneity in host susceptibility to tuberculosis is proposed, with the aim of investigating the implications this may have for the effectiveness of public health interventions. The model examines the possibility that recovered individuals treated from active TB and individuals treated with preventive therapy acquire different levels of immunity. This contrasts with recent studies that assume the two cohorts acquire the same level of immunity, and therefore both groups are reinfected at the same rate. The analysis presented here examines the impact of this assumption when designing intervention strategies. Comparison of reinfection rates between..
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Awarded by Australian Research Council
Funding Acknowledgements
[ "James Trauer is a recipient of an Early Career Fellowship from the Australian National Health and Medical Research Council, APP1142638. Lewi Stone is a recipient of an Australian Research Council Discovery Grant DP170102303. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.", "We thank James Trauer from School of Public Health and Preventive Medicine, Monash university for his helpful suggestions that significantly improved the manuscript. James Trauer is a recipient of an Early Career Fellowship from the Australian National Health and Medical Research Council, APP1142638." ]