Tranexamic acid in coronary artery surgery: One-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial

PS Myles; JA Smith; J Kasza; B Silbert; M Jayarajah; T Painter; DJ Cooper; S Marasco; J McNeil; JS Bussières; S McGuinness; K Byrne; MTV Chan; G Landoni; S Wallace; A Forbes; D Esmore; H Krum; A Tonkin; B Buxton; S Heritier; A Merry; D Liew; A Meehan; W Galagher; C Farrington; A Ditoro; L Wutzlhofer; D Story; P Peyton; S Baulch; S Sidiropoulos; D Potgieter; RA Baker; B Pesudovs; E O'Loughlin J Wells; P Coutts; S Bolsin; C Osborne; K Ives; A Hulley; G Christie-Taylor; S Lang; H Mackay; C Cokis; S March; PG Bannon; C Wong; L Turner; D Scott; S Said; P Corcoran; L de Prinse; N Gagné; A Lamy; L Semelhago; M Underwood; GSY Choi; B Fung; R Lembo; F Monaco; F Simeone; D Marianello; G Alvaro; G De Vuono; D van Dijk; J Dieleman; S Numan; R Parke; P Raudkivi; E Gilder; J Dunning; J Termaat; G Mans; J Alderton; D Waugh; MJ Platt; A Pai; A Sevillano; A Lal; C Sinclair; G Kunst; A Knighton; GM Cubas; P Saravanan; R Millner; V Vasudevan; M Patteril; E Lopez; R Basu; J Lu

Journal article

Tranexamic acid in coronary artery surgery: One-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial

PS Myles, JA Smith, J Kasza, B Silbert, M Jayarajah, T Painter, DJ Cooper, S Marasco, J McNeil, JS Bussières, S McGuinness, K Byrne, MTV Chan, G Landoni, S Wallace, A Forbes, D Esmore, H Krum, A Tonkin, B Buxton Show all

Journal of Thoracic and Cardiovascular Surgery | MOSBY-ELSEVIER | Published : 2019

DOI: 10.1016/j.jtcvs.2018.09.113

Abstract

Background: Tranexamic acid reduces blood loss and transfusion requirements in cardiac surgery but may increase the risk of coronary graft thrombosis. We previously reported the 30-day results of a trial evaluating tranexamic acid for coronary artery surgery. Here we report the 1-year clinical outcomes. Methods: Using a factorial design, we randomly assigned patients undergoing coronary artery surgery to receive aspirin or placebo and tranexamic acid or placebo. The results of the tranexamic acid comparison are reported here. The primary 1-year outcome was death or severe disability, the latter defined as living with a modified Katz activities of daily living score of less than 8. Secondary ..

View full abstract

University of Melbourne Researchers

Brendan Silbert Author

David Story Author

Philip Peyton Author

Grants

Awarded by National Institute for Health Research

Funding Acknowledgements

The study sponsor was the Alfred Hospital, Melbourne, Australia. The study was supported by grants from the Australian National Health and Medical Research Council (NHMRC, ID 334015 and 1009203); the Australian and New Zealand College of Anaesthetists; and the UK National Institute of Health Research. Paul Myles is supported by an Australian NHMRC Practitioner's Fellowship.