Journal article

Pancreatic cancer as a sentinel for hereditary cancer predisposition

Erin L Young, Bryony A Thompson, Deborah W Neklason, Matthew A Firpo, Theresa Werner, Russell Bell, Justin Berger, Alison Fraser, Amanda Gammon, Cathryn Koptiuch, Wendy K Kohlmann, Leigh Neumayer, David E Goldgar, Sean J Mulvihill, Lisa A Cannon-Albright, Sean V Tavtigian

BMC CANCER | BMC | Published : 2018


BACKGROUND: Genes associated with hereditary breast and ovarian cancer (HBOC) and colorectal cancer (CRC) predisposition have been shown to play a role in pancreatic cancer susceptibility. Growing evidence suggests that pancreatic cancer may be useful as a sentinel cancer to identify families that could benefit from HBOC or CRC surveillance, but to date pancreatic cancer is only considered an indication for genetic testing in the context of additional family history. METHODS: Preliminary data generated at the Huntsman Cancer Hospital (HCH) included variants identified on a custom 34-gene panel or 59-gene panel including both known HBOC and CRC genes for respective sets of 66 and 147 pancreat..

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University of Melbourne Researchers


Awarded by United States National Institutes of Health (NIH) National Cancer Institute (NCI)

Awarded by NCI

Awarded by NIH NCI Cancer Center Support Grant

Awarded by National Human Genome Research Institute

Funding Acknowledgements

[ "This research was supported by United States National Institutes of Health (NIH) National Cancer Institute (NCI) grant R01CA164138; NCI grant P30CA042014 (support of Genetic Counseling Shared Resource), by the Utah Genome Project; by the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer program; by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, and the Ministere de l'enseignement superieur, de la recherche, de la science, et de la technologie du Quebec through Genome Quebec; by NIH NCI Cancer Center Support Grant P30CA042014; and by the Huntsman Cancer Foundation.", "BAT is a National Health and Medical Research Council CJ Martin Early Career Fellow. ELY was supported by the National Institutes of Health under Ruth L. Kirschstein National Research Service Award T32HG008962 from the National Human Genome Research Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health." ]