Journal article

Interleukin 11 blockade during mid to late gestation does not affect maternal blood pressure, pregnancy viability or subsequent fertility in mice

Amy Winship, Ellen Menkhorst, Michelle Van Sinderen, Evdokia Dimitriadis

REPRODUCTIVE BIOMEDICINE ONLINE | ELSEVIER SCI LTD | Published : 2018

Abstract

Interleukin (IL)11 is a crucial regulator during the initiation of pregnancy in humans and mice. Elevated levels are detected in serum, placenta and decidua of women with pre-eclampsia. Elevated IL11 during placentation recapitulates pre-eclampsia in mice, although withdrawal rescues pre-eclampsia features, suggesting that IL11 could provide a novel therapeutic target. The aim of this study was to determine the safety profile of an IL11 antagonist ligated to polyethylene glycol (PEGIL11A) during pregnancy in mice. Blocking IL11 signalling during mid to late gestation pregnancy in mice did not affect pregnancy viability, or alter placental or fetal weight, or morphology. Importantly, decidual..

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Grants

Awarded by NHMRC Australia Project Grant


Awarded by NHMRC Australia Senior Research Fellowship


Funding Acknowledgements

The authors acknowledge CSL Limited for providing the PEGIL11A and PEG control reagents. This work was supported by NHMRC Australia Project Grant (1078674) and the Victorian Government's Operational Infrastructure Support Program. AW was supported by a Cancer Council Victoria Postdoctoral Fellowship. ED was supported by a NHMRC Australia Senior Research Fellowship (550905).