Interleukin 11 is upregulated in preeclampsia and leads to inflammation and preeclampsia features in mice
Amy Winship, Eva Dimitriadis
Journal of Reproductive Immunology | ELSEVIER IRELAND LTD | Published : 2018
Preeclampsia is a dangerous pregnancy complication, which is often associated with fetal growth restriction and can have serious life-long effects for both mother and baby. While the establishment of the placenta in the first trimester is the sentinel event in the development of preeclampsia little is known of the critical mechanisms of placentation that lead to the syndrome. Locally produced inflammatory cytokines are thought to play a role in the development of preeclampsia. This review summarizes the evidence that interleukin 11 is dysregulated in preeclampsia and contributes to the initiation of preeclampsia via effects on placentation. It discusses the benefits and drawbacks of targetin..View full abstract
Awarded by NHMRC Australia Project
Awarded by NHMRC Australia Senior Research Fellowship
This work was supported by NHMRC Australia Project Grant (1078674) and the Victorian Government's Operational Infrastructure Support Program. ED was supported by a NHMRC Australia Senior Research Fellowship (550905). AW was supported by a Cancer Council Victoria Postdoctoral Fellowship.